Conserved neural circuits for survival

Bach DR, Naef M, Deutschmann M, Tyagarajan SK, Quednow BB (2019). Threat memory reminder under matrix metalloproteinase 9 inhibitor doxycycline globally reduces subsequent memory plasticity. Journal of Neuroscience, in press. [Open Data] [Open Code]

Bach DR, Hoffmann M, Finke C, Hurlemann R, Ploner CJ (2019). Disentangling hippocampal and amygdala contribution to human anxiety-like behaviour. Journal of Neuroscience, in press. [Full Text]

Oberrauch S, Sigrist H, Sautter E, Gerster S, Bach DR, Pryce CR (2019). Establishing operant conflict tests for the translational study of anxiety in mice. Psychopharmacology, 236, 2527-2541. PDF

Tzovara T, Meyer SS, Bonaiuto JJ, Abivardi A, Dolan RJ, Barnes GR, Bach DR (2019). High-precision magnetoencephalography for reconstructing amygdalar and hippocampal oscillations during prediction of safety and threat. Human Brain Mapping, 40, 4114-4129. PDF

Bach DR, Korn CW, Vunder J, Bantel A (2018). Effect of valproate and pregabalin on human anxiety-like behaviour in a randomised controlled trial. Translational Psychiatry, 8, 157. PDF

Bach DR, Tzovara A, Vunder J (2018). Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline. Molecular Psychiatry, 23, 1584–1589. PDF

Staib M & Bach DR (2018). Stimulus-invariant auditory cortex threat encoding during fear conditioning with simple and complex sounds. Neuroimage, 166, 276-284. PDF

Khemka S, Barnes G, Dolan RJ, Bach DR (2017). Dissecting the function of hippocampal oscillations in a human anxiety model. Journal of Neuroscience, 37, 6869-6876. PDF

Abivardi A & Bach DR (2017). Deconstructing white matter connectivity of human amygdala nuclei with thalamus and cortex subdivisions in vivo. Human Brain Mapping, 38, 3927-3940. PDF

Korn CK, Vunder J, Miro J, Fuentemilla L, Hurlemann R, Bach DR (2017). Amygdala lesions reduce anxiety-like behavior in a human benzodiazepine-sensitive approach-avoidance conflict test. Biological Psychiatry, 82, 522-531. PDF

Bach DR, Symmonds M, Barnes G, Dolan RJ (2017). Whole-brain neural dynamics of probabilistic reward prediction. Journal of Neuroscience, 37, 3789-3798. PDF

Bach DR, Hurlemann R, Dolan RJ (2015). Impaired threat prioritisation after selective bilateral amygdala lesions. Cortex, 63, 206-213. PDF

Bach DR, Furl N, Barnes G, Dolan RJ (2015). Sustained Magnetic Responses in Temporal Cortex Reflect Instantaneous Significance of Approaching and Receding Sounds. PLOS ONE, 10, e0134060. PDF

Bach DR, Seifritz E, Dolan RJ (2015). Temporally unpredictable sounds exert a context-dependent influence on evaluation of unrelated images. PLOS ONE, 10, e0131065. PDF

Bach DR, Guitart-Masip M, Packard PA, Miró J, Falip M, Fuentemilla L, Dolan RJ (2014). Human hippocampus arbitrates approach-avoidance conflict. Current Biology, 24, 541-547. PDF


Algorithms for survival

Korn CW & Bach DR (2019). Minimizing threat via heuristic and optimal policies recruits hippocampus and medial prefrontal cortex. Nature Human Behavior, 3(7):733-745. PDF

Tzovara A, Korn CW & Bach DR (2018). Human Pavlovian fear conditioning conforms to probabilistic learning. PLOS Computational Biology,14, e1006243. PDF

Korn CW & Bach DR (2018). Heuristic and optimal policy computations in the human brain during sequential decision-making. Nature Communications, 9, 325. PDF

Bach DR, & Dayan, P (2017). Algorithms for survival: a comparative perspective on emotions. Nature Reviews Neuroscience, 18, 311-319. PDF

Bach DR (2017). The cognitive architecture of anxiety-like behavioural inhibition. Journal of Experimental Psychology: Human Perception and Performance, 43,18-29. PDF

Bach DR (2015). Anxiety-like behavioural inhibition is normative under environmental threat-reward correlations. PLOS Computational Biology, 11, e1004646. PDF

Korn CW & Bach DR (2015). Maintaining Homeostasis by Decision-Making. PLOS Computational Biology, 11, e1004301. PDF

Bach DR (2015). A cost minimisation and Bayesian inference model predicts startle reflex modulation across species. Journal of Theoretical Biology, 370, 53-60. PDF


Behavioural research methods

Melinscak F, Bach DR (2020). Computational optimization of associative learning experiments. PLOS Computational Biology,16(1), e1007593. [Full text] [OSF project] [Code]

Xia Y, Gurkina A, Bach DR (2019). Pavlovian-to-instrumental transfer after human threat conditioning. Learning & Memory, 26, 167-175. PDF

Bach DR, Castegnetti G, Korn CW, Gerster S, Melinscak F, Moser T (2018). Psychophysiological modelling – current state and future directions. Psychophysiology, 55, e13209. PDF

Gerster S, Namer B, Elam M, Bach DR (2018). Testing a linear time invariant model for skin conductance responses by intraneural recording and stimulation. Psychophysiology, 55, e12986. PDF

Korn CK, Staib M, Tzovara A, Castegnetti G, Bach DR (2017). A pupil size response model to assess fear learning. Psychophysiology, 54, 330-343. PDF

Castegnetti G, Tzovara A, Staib M, Gerster S, Bach DR (2017). Assessing fear learning via conditioned respiratory amplitude responses. Psychophysiology, 54, 215-223. PDF

Khemka S, Tzovara A, Gerster S, Quednow BB, Bach DR (2017). Modelling startle eye blink electromyogram to assess fear learning. Psychophysiology, 54, 202-214. PDF

Bach DR, Gerster S, Tzovara A, Castegnetti G (2016). A linear model for event-related respiration responses. Journal of Neuroscience Methods270, 174-155. PDF

Castegnetti G, Tzovara A, Staib M, Paulus PC, Hofer N, & Bach DR (2016). Modelling fear-conditioned bradycardia in humans. Psychophysiology, 53, 930-939. PDF

Korn CW & Bach DR (2016). A solid frame for the window on cognition: Modelling event-related pupil responses. Journal of Vision, 16:28,1-6. PDF

Paulus PC, Castegnetti G, & Bach DR (2016). Modeling event-related heart period responses. Psychophysiology, 53, 837-846.  PDF

Bach DR, Staib M (2015). A matching pursuit algorithm for inferring tonic sympathetic arousal from spontaneous skin conductance fluctuations. Psychophysiology, 52, 1106-12. PDF

Staib M, Castegnetti G, Bach DR (2015). Optimising a model-based approach to inferring fear learning from skin conductance responses. Journal of Neuroscience Methods, 255, 131-138. PDF


Emotion circuit malfunction

Bach DR, Brown SA, Kleim B, Tyagarajan SK (2019). Extracellular matrix: a new player in memory maintenance and psychiatric disorder. Swiss Medical Weekly, 149:w20060. PDF

Stephan KE, Bach DR, Fletcher PC, Flint J, Frank MJ, Friston KJ, Heinz A, Huys QJ, Owen MJ, Binder EB, Dayan P, Johnstone EC, Meyer-Lindenberg A, Montague PR, Schnyder U, Wang XJ, Breakspear M (2016). Charting the landscape of priority problems in psychiatry, part 1: classification and diagnosis. Lancet Psychiatry3, 77-83. PDF